If you plan to carry a heavy pack on your pack, test it out first to make sure you can handle the weight. Pack a few days in advance, put the bag on your back, and walk around - go up and down some stairs, and see how it feels. You may discover that you can't handle the load, and need to readjust your luggage.
It's way better to find this out a few days before you leave, rather than get stuck carrying around a super-heavy load on your trip!

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