Be sure to bring essentials with you on the plane in your carry-on luggage. This includes things like medication, eye drops, eyeglasses, motion sickness medication, etc.
It's easier if you have a smaller, separate bag for these types of essentials, so you don't have to dig through your entire carry-on bag just to find one tiny bottle of eye drops. You can keep this smaller bag under the seat in front of you for easy access.
Also pack a book, magazine, sketchbook, mp3 player, or anything else that will ward off boredom during the flight.

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